Osteoclasts Are Required for Hematopoietic Stem and Progenitor Cell Mobilization but Not for Stress Erythropoiesis in Plasmodium chabaudi adami Murine Malaria

Figure 1

Impact of calcitonin on Plasmodium chabaudi adami parasitemia and anemia. Mice were treated with calcitonin (Cal-DK) or PBS (Ctl and DK) during 5 consecutive days. P. c. adami DK parasites (10⁵ pRBCs) were inoculated on the 3rd day of treatment. Four mice of each infected group and 4 uninfected controls were sacrificed at 5 day after infection and C-telopeptide of type I collagen (CTX) levels were assessed in the plasma by ELISA (a). Parasitemia was monitored daily for determination of the kinetics of infection (b) and cumulative parasitemia (c). Hemoglobin levels (d) and reticulocytosis (e) were measured in the blood. Data are mean ± SEM and represent the compilation of three experiments (a total of 14–18 mice per infected group); values are compared using a nonparametric Student’s -test. ; ; .

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