miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose

Figure 1

Decrease in miR-146a expression in REC in high glucose and transfection-induced fold changes. (a) Fold changes of miR-146a expression are shown. After 3 days of REC culture in high glucose (25 mM) medium, the expression of miR-146a was reduced, 0.5-fold change, compared to that of normal glucose (NG; 5 mM) group. (b) Transfection-induced fold changes of miR-146a expression in REC. REC were transfected with mimics (50 nM of final concentration) of miR-146a to increase the level of expression in a hyperglycemic condition. The -axis is a logarithmic scale. versus NG, versus HG; . Data are mean ± SEM.

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