miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose

Figure 2

Effects of miR-146a on HMGB1 levels in hyperglycemia. REC were cultured in normal glucose (5 mM, NG) or high glucose (25 mM, HG). High glucose increased HMGB1 levels, which were significantly decreased in REC after miR-146a overexpression. A representative blot is shown. versus NG, versus HG, and versus miR-146a; . Data are mean ± SEM.