miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose

Figure 4

Changes of MyD88-independent signaling, TRIF and IRF3 levels, in REC. REC were cultured in normal glucose (5 mM, NG) or high glucose (25 mM, HG). Overexpression of miR-146a decreased the levels of TRIF (a) and IRF3 (b) in REC, compared to that of control HG group. A representative blot is shown. versus NG, versus HG, and versus miR-146a. A minimum of was used for all data. Data are mean ± SEM.

(a)

(b)