A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis

Figure 2

A schematic representing the involvement of different organs in sepsis. During sepsis large amounts of inflammatory mediators are found within the bloodstream. They can act on different organs and induce tissue injury that in turn will favour further production of inflammatory mediators. Cross talk between the different organs and tissues is further mediated by the local delivery of mediators that can amplify or limit the inflammatory response (MIF, macrophage migration inhibitory factor; NO, nitric oxide; ROS, reactive oxygen species; RNS, reactive nitrogen species; VCAM-1, vascular adhesion molecule-1; and ICAM-1, intercellular adhesion molecule-1).