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Mediators of Inflammation
Volume 2016 (2016), Article ID 4097574, 8 pages
http://dx.doi.org/10.1155/2016/4097574
Research Article

MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations

1Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, Germany
2Psoriasis Research and Treatment Center, University Hospital Charité, Berlin, Germany
3Berlin-Brandenburg Center for Regenerative Therapies, University Hospital Charité, Berlin, Germany
4Department of Dermatology and Allergy, University Hospital Charité, Berlin, Germany
5Institute of Medical Immunology, University Hospital Charité, Berlin, Germany
6Research Center Immunosciences, University Hospital Charité, Berlin, Germany

Received 25 May 2016; Accepted 4 September 2016

Academic Editor: Giuseppe Valacchi

Copyright © 2016 Athanasia Tsaousi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I. Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-α stimulation. Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8. The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-α blood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas. Additionally, we found a negative correlation between blood MMP8 and HDL-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI. In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment.