Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

Figure 4

Determination of the optimal dose of TAK-242. (a) The effects of different doses of TAK-242 (0.1, 0.5, or 1 mg/kg) on DAI were determined via western blotting and measurement of β-APP expression. (b) The bar graphs show the β-APP expression results in the cortex after administration of different doses of TAK-242. The expression of β-actin was used as an internal control. Values are presented as the mean ± SD (; , compared with control group; , compared with DAI 1 d+vehicle group; , , compared with DAI 1 d+TAK-242 (0.5 mg/kg) group).

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