Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

<div>The protective role of TLR4 inhibition in DAI. (a) H&amp;E staining and <i>β</i>-APP immunohistochemistry were performed to assess the pathological changes in the control, DAI 1 d, DAI 1 d+vehicle, and DAI 1 d+TAK-242 groups. (b) The bar graphs show the <i>β</i>-APP immunohistochemistry results for all groups. <i>β</i>-APP immunoreactivity was assessed in 5 random fields (40x magnification) via immunohistochemical scores (IHS). 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Mediators of Inflammation

fig6

Figure 6

Figure 6: Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats 