|
| Markers used to identify subset | Reference | Frequency | Phenotype | Function |
|
| BDCA1+ | Fiore et al. [78] | ↓ blood in active disease and
↑ kidney in active disease | DCs in kidney were immature (DC-LAMP−), localized to tubulointerstitium | |
|
| BDCA3+ | Fiore et al. [78] | ↓↓ blood and
↑ kidney in active disease | DCs in kidney were immature (DC-LAMP−), localized to tubulointerstitium, with elongated processes | |
|
| BDCA1+ CD11c+ BDCA4− CD19− | Jin et al. [91] | ↓ in blood per total PBMC | ↓ CD83, especially in active disease,
normal HLA-DR, CD86, and CCR7 | |
|
| HLA-DR+ Lin− CD4+ | Scheinecker et al. [76] | ↓ in blood | ↓ CD40+, B7+, and CD11c+ | ↓ T cell proliferation in MLR |
|
| BDCA1+ CD11c+ | Tucci et al. [82] | Normal in blood, relatively few in kidney | | |
|
| CD11c+ Lin− | Crispín et al. [83] | ↑ in blood (though not significant) | ↑ CD86+, CD80+, normal HLA-DR+, and CD40+ | Normal T cell proliferation in MLR, moDCs fail to increase costimulatory molecule expression upon activation |
|
| CD14− | Gerl et al. [81] | na | ↑ CD86, BAFF, normal HLA-DR, CD83, CD40, CCR7, CCR1, and CCR5 and ↓ CMKLR1 | |
|
| Adherent, monocyte-derived DCs (MDDCs) | Ding et al. [93] | na | ↑ CD86, CD80, HLA-DR, and CD1a and
↓ CD83 after 5–7 d culture | ↑ T cell proliferation in MLR |
|
| CD14+ sorted, monocyte-derived DCs (MDDCs) | Köller et al. [92] | na | ↓ HLA-DR after 8–10 d culture, normal CD86, CD83, CD80, CD40, CD54, and CD33 | ↑ antigen-specific T cell proliferation and normal MLR |
|
| M-DC8 (slanDCs) | Hänsel et al. [53] | ↑ in skin of patients with cutaneous LE and “strong inflammation” SLE | In situ TNF production in cutaneous LE | ↑ TNFα production by healthy donor slanDCs in response to SLE serum compared with control serum |
|
