MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence

Table 1

The major components of EC junction and their targeting miRNAs.

Junction protein	Targeting miRNAs	Clinical consequence
ZO-1/occludin/claudin-5	miR-105, miR-181a, miR-18a, miR-21, miR-150, miR-101, miR-126	EC barrier disruption; Tumorigenesis
VE-cadherin	miR-99b, miR-181a, miR-181b, miR-21, miR-125b, miR-142a-3p, miR-101, miR-27a, miR-302c, miR-26b-5p, miR-20a	EC barrier disruption Tumorigenesis
β-Catenin	miR-1826, miR-23b	Growth, apoptosis, invasion
PECAM-1	miR-126, miR-155	EC barrier disruption; Tumorigenesis
Integrin β4	miR-184, miR-205, miR-9	Tumor metastasis
Paxillin	miR-137, miR-145, miR-218, miR-125b	Tumor metastasis; Infection
FAK	miR-135, miR-138, miR-543	Tumorigenesis; Tumor invasion