Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord

Figure 1

Radiotherapy relieved thermal hyperalgesia and mechanical allodynia in TCI rats. Thermal hyperalgesia of the hind paw ipsilateral (a) and contralateral (b) to TCI. Mechanical allodynia of the hind paw ipsilateral (c) and contralateral (d) to TCI. Arrows indicate administration of X-radiation (6 Gy) on the 9th day after surgery. Eight rats were included in each group. , versus sham; , versus TCI + sham radiotherapy.

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