Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

Figure 4

The TGF-β signaling pathway in kidney tissue 5 weeks after DXR injection in different groups of mice as indicated. (a) DAL inhibits the phosphorylation of Smad3; (b) DAL inhibits the gene expression of collagen III, which is the target gene of Smad3; (c) DAL inhibits the protein expression of collagen III, which is the target protein expression of Smad3. The control and DAL treatment groups are compared with the DXR group. Values are statistically significant at ; the DXR group is compared with the control group. Values are statistically significant at .

(a)

(b)

(c)