Frequency of TNFA, INFG, and IL10 Gene Polymorphisms and Their Association with Malaria Vivax and Genomic Ancestry

Table 2

Distribution of the genotypes between vivax malaria-infected and noninfected individuals.

Gene	SNP	Genotype	Malaria			Noninfected			p value
			(%)	MAF	HWE	(%)	MAF	HWE
IFNG	+874A>T	AA	39 (48.7)	0.30	0.91	17 (34.0)	0.37	0.08	0.22
		AT	34 (42.5)			29 (58.0)
		TT	7 (8.8)			4 (8.0)
TNFA	-1031T>C	TT	51 (56.7)	0.28	0.11	24 (47.1)	0.28	0.14	0.53
		TC	37 (41.1)			25 (49.0)
		CC	2 (2.2)			2 (3.9)
TNFA	-308G>A	GG	69 (76.7)	0.12	0.21	35 (68.7)	0.18	0.69	0.14
		GA	21 (23.3)			14 (27.4)
		AA	0			2 (3.9)
TNFA	-238G>A	GG	80 (88.9)	0.06	0.22	46 (90.2)	0.05	0.71	0.70
		GA	9 (10.0)			5 (9.8)
		AA	1 (1.1)			0
IL10	-819C>T	CC	39 (43.3)	0.34	0.87	19 (37.2)	0.35	0.15	0.55
		CT	41 (45.6)			28 (54.9)
		TT	10 (11.1)			4 (7.8)
IL10	-592C>A	CC	41 (45.6)	0.29	0.05	20 (39.2)	0.34	0.21	0.62
		CA	45 (50.0)			27 (52.9)
		AA	4 (4.4)			4 (7.8)

MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium.
values were calculated from a chi-squared test.