Frequency of TNFA, INFG, and IL10 Gene Polymorphisms and Their Association with Malaria Vivax and Genomic Ancestry
Table 4
Haplotype frequency and its association with the proportions of African, European, and Native American ancestry.
Haplotype
Frequency
African
European
Native American
Proportion
Difference (95% CI)
value
Proportion
Difference (95% CI)
value
Proportion
Difference (95% CI)
value
T/G/G
0.615
0.31
Reference
0.44
Reference
0.25
Reference
C/G/G
0.191
−0.01 (−0.05–0.03)
0.61
−0.01 (−0.06–0.03)
0.57
0.01 (−0.02–0.05)
0.49
T/A/G
0.121
−0.05 (−0.10–0.00)
0.05
0.06 (0.00–0.11)
0.05
−0.02 (−0.06–0.02)
0.37
C/G/A
0.044
−0.01 (−0.08–0.06)
0.78
−0.02 (−0.11–0.06)
0.55
0.06 (−0.03–0.15)
0.17
C/C
0.650
0.30
Reference
0.45
Reference
0.25
Reference
T/A
0.303
−0.01 (−0.04–0.03)
0.67
0.00 (−0.04–0.04)
0.94
0.01 (−0.02–0.04)
0.55
T/C
0.040
0.01 (−0.07–0.08)
0.86
−0.02 (−0.10–0.06)
0.60
0.02 (−0.05–0.08)
0.63
The effects of each haplotype were relative to the most frequent haplotype used as a reference. indicates relative change in the ancestry proportions compared to the reference haplotypes with 95% confidence intervals.
