Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications

Table 1

Hallmarks on the understanding of the role of the Th17 pathways in MS.

Finding	Reference
Increased IL-17 found in the blood and CSF of RRMS patients, especially during relapse	[43]
IL-17-producing T cells identified in EAE	[10]
Increased Th17 cells and IL-17 found in the brain of MS patients	[48]
IL-17 production correlates with MRI activity	[53]
Secukinumab (anti-IL-17A monoclonal antibody) reduces MRI lesions in a phase II clinical trial	[114]