Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications

Table 2

Hallmarks on the understanding of the role of the Th17 pathways in NMOSD.

Finding	Reference
Increased IL-17 found in the CSF of NMO patients	[60]
Increased Th17 cells found in the blood of NMO patients, especially during relapse	[69]
IL-17 and subsets of Th17 correlate with EDSS and relapse frequency in NMO	[54]
Pathogenicity of AQP4-specific T cells demonstrated in animal models	[65]
Pathogenicity of Th17-polarized AQP4-specific T cells demonstrated in animal models	[67]