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Mediators of Inflammation
Volume 2016, Article ID 5414369, 7 pages
http://dx.doi.org/10.1155/2016/5414369
Research Article

Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease

1Department of Medical Biology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey
2Department of Dermatology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey
3Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey
4Department of Ophthalmology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey
5Department of Immunology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Turkey

Received 16 March 2016; Revised 19 May 2016; Accepted 29 May 2016

Academic Editor: Marc Pouliot

Copyright © 2016 Sevgi Irtegun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Behçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-α production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.