Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites

Table 1

The overview shows the relative expression of IL-1β in relation to clinical parameters. ICU: necessity of intensive care treatment; sepsis: fulfilment of clinical sepsis criteria; empyema: fulfilment of clinical empyema criteria; preinfectious joint damage: any lesion including osteoarthritis; in-hospital treatment: the difference to an outpatient treatment (< or ≥0.005, -test; ICU: intensive care unit, n.s.: not significant).

Symptom	Group	(yes/no)	High IL-1β—yes (%)	High IL-1β—no (%)
ICU	All	22/54	59.1	29.6	0.008
	Knees	16/41	56.3	29.3	0.029
Sepsis	All	12/64	58.3	34.4	n.s.
	Knees	8/49	50.0	34.7	n.s.
Empyema	All	47/29	51.1	17.2	0.0016
	Knees	34/23	47.1	21.7	0.025
Preinfectious joint damage	All	50/26	48.0	19.2	0.007
	Knees	37/20	43.2	25.0	n.s.
In-hospital treatment	All	69/7	42.0	0.0	0.014
	Knees	51/6	41.2	0.0	0.024