Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases

Figure 3

Anti-inflammatory mechanisms of MFG-E8 in a LPS-TLR4 signaling pathway. (a) Apoptotic cell-dependent anti-inflammatory role of MFG-E8. MFG-E8 mediates the phagocytosis of apoptotic cells, leading to the suppression of proinflammatory cytokine production through the inhibition of NF-κB and MAPK signaling pathways. (b) Apoptotic cell-independent anti-inflammatory role of MFG-E8. MFG-E8 binds with integrin and induces STAT3-mediated SOCS3 activation, leading to the inhibition of the NF-κB signaling pathway, thereby suppressing the production of proinflammatory cytokines.

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