Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases

Table 1

Altered expression of MFG-E8 in human diseases.

Factors	Localization	References
Upregulation of MFG-E8
Fractalkine (CX3CL1)	Microglial cell, macrophage	[25]
GM-CSF	Macrophage, antigen presenting cell	[26]
Prolactin	Mammary epithelial cell, macrophage	[27, 28]
PPAR-	Macrophage	[29]
Lung fibrosis	Lung	[22]
Melanoma	Skin	[30]
Breast cancer	Breast	[31]
SLE	Blood	[32]
Downregulation of MFG-E8
LPS	Macrophage, spleen, and blood	[33, 34]
Connexin 43	Mammary epithelial cell	[35]
Rheumatoid arthritis	Joints	[36]
Sepsis	Macrophage, spleen, and blood	[34, 37–40]
Acute colitis	Intestine	[20]
Atherosclerosis	Cardiovascular endothelial cell	[41]
Ischemia/reperfusion injury	Gut, spleen	[42]
Alzheimer’s disease	Brain	[43]
Autoimmune diseases	Spleen, lymph node, and kidney	[18]