Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

Figure 1

Nlrp3−/− mice exhibit enhanced susceptibility to DSS-induced colitis, a phenotype that associated with reduced IL-10 expression. (a) Changes in body weight during a 7-day course of DSS (3.5% w/v in drinking water) in WT and Nlrp3−/− mice. denotes compared to WT; /group. (b) Colonic tissue myeloperoxidase (MPO) levels assessed in WT and Nlrp3−/− mice on day 7 of DSS. denotes compared to WT mice; /group. (c) Flow cytometric analysis of IL-10 expression in CD4+ and CD8+ T cells from the LP of WT and Nlrp3−/− mice on day 7 of DSS. denotes compared to WT mice; /group. (d) Flow cytometric analysis of total CD4+/CD3+ and (e) CD8+/CD4+ cells isolated from the LP of WT and Nlrp3−/− mice on day 7 of DSS; /group.

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