Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins

Figure 2

Flow cytometry analysis of the expression of IFN-λ2 in peripheral blood leukocytes. (a) (A), (B), (C), (D), (E), (F), (G), (H), (I), (J), and (K) showed a representative graph of the changes in mean fluorescent intensity in CD19+ cells (B cells), CD8+ cells (cytotoxic T cells), CD16− polynucleated cells (eosinophils), CD4+ cells (helper T cells), CD14+ cells (monocytes), CD16+ cells (neutrophils), CD123+HLA-DR− cells, CD4+INF-γ+ cells (Th1 cells), CD4+IL-4+ cells (Th2 cells), CD4+IL-17A+ cells (Th17 cells), and CD4+CD25+FOXP3+ cells (regulatory T cells) in allergic rhinitis (AR), asthma (AS), and combined AR and AS (AR + AS) and healthy control subjects (HC), respectively. IC = isotype control. (b) represents boxplot analysis of the expression of IFN-λ2 in peripheral blood leukocytes. Data are displayed as a boxplot for AR (), AS (), AR + AS (), and HC (), which indicates the median, the interquartile range, and the largest and smallest values for the number of subjects indicated. , increased value compared with HC. , decreased value compared with HC.