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Mediators of Inflammation
Volume 2016 (2016), Article ID 5780903, 7 pages
Research Article

Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis

1Surgery Department, The District Hospital, 22 Szpitalna Street, 34-200 Sucha Beskidzka, Poland
2Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, 12 Kopernika Street, 31-034 Krakow, Poland
3Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland
4St’Queen Jadwiga Clinical District Hospital No. 2, 60 Lwowska Street, 35-301 Rzeszow, Poland
5Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland
6Institute of Physics, Department of Medical Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, 11 Lojasiewicza Street, 30-348 Krakow, Poland
7Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, 15c Kopernika Street, 31-501 Krakow, Poland
8Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 15a Kopernika Street, 31-501 Krakow, Poland

Received 3 November 2015; Revised 19 January 2016; Accepted 28 January 2016

Academic Editor: Pham My-Chan Dang

Copyright © 2016 Mateusz Sporek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Within the first week of the disease, acute kidney injury (AKI) is among the most common causes of mortality in acute pancreatitis (AP). Recently, serum angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the systemic circulation. The aim of this study was to examine the associations between Ang-2 and the clinical AP severity during the first 72 hours of the disease, and organ disfunction, including AKI. Methods. Study included patients admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to KDIGO guidelines and renal failure according to modified Marshall scoring system. Ang-2 was determined in serum with ELISA. Results. AP was classified as mild (MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in 8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms significantly predicted SAP and MSAP, as well as AKI and renal failure. Also, Ang-2 significantly correlated with acute phase proteins as well as with the indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant predictor of AP severity, in particular of the development of AP-renal syndrome.