Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

Figure 1

Effect of metformin in mice fed a high-fat diet. Obesity was induced in C57BL/6J mice and then 10 mg/kg or 50 mg/kg metformin (), or saline () was administered orally on a daily basis to obese mice. (a) Body weight (mean ± SEM) was recorded in mice treated with metformin (10 mg/kg or 50 mg/kg) and compared to control mice. (b) Untreated obese mice or metformin-treated obese mice had different metabolic profiles. (c) Glucose tolerance test (GTT) and insulin tolerance test (ITT) in untreated obese mice and metformin-treated obese mice over 14 weeks.

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