CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects
Table 2
Association between CRP and SAA levels and measurable risk factors in Taiwanese.
Clinical and biochemical parameters
CRP level
SAA level
(95% CI)
value
Adjusted value
(95% CI)
value
Adjusted value
Anthropology
Body mass index
0.318
0.045 (0.034–0.056)
1.9 × 10−15
6.1 × 10−14
0.121
0.017 (0.006–0.028)
0.003
0.096
Waist-hip ratio
0.221
1.793 (1.157–2.430)
4.7 × 10−8
1.5 × 10−6
0.061
0.488 (−0.156–1.131)
0.137
NS
Blood pressure
Systolic BP
0.178
0.006 (0.003–0.008)
3.6 × 10−5
0.001
0.132
0.004 (0.001–0.007)
0.003
0.096
Diastolic BP
0.152
0.008 (0.003–0.012)
4.4 ×10−4
0.014
0.141
0.007 (0.003–0.011)
0.001
0.032
Glucose metabolism
Fasting plasma glucose
0.139
1.056 (0.493–1.618)
0.001
0.032
0.002
0.001 (−0.568–0.570)
0.996
NS
HOMA-IR index
0.299
0.778 (0.605–0.951)
1.2 × 10−17
3.9 × 10−16
0.138
0.335 (0.151–0.519)
0.001
0.032
Lipid profiles
LDL cholesterol
0.055
0.001 (0.000–0.002)
0.185
NS
0.032
<0.001 (−0.001–0.002)
0.449
NS
HDL cholesterol
−0.246
−1.161 (−1.532 to −0.790)
1.4 × 10−9
4.6 × 10−8
0.074
0.345 (−0.036–0.725)
0.076
NS
Triglyceride
0.267
0.528 (0.373–0.683)
5.0 × 10−11
1.6 × 10−9
0.095
0.186 (0.026–0.345)
0.022
0.704
Renal function
Urinary ACR
0.011
<0.001
0.783
NS
0.028
<0.001
0.501
NS
Uric acid
0.227
0.077 (0.048–0.106)
3.8 × 10−7
1.2 × 10−5
0.131
0.043 (0.014–0.071)
0.004
0.128
eGFR
0.196
0.006 (0.003–0.008)
1.1 × 10−5
3.5 × 10−4
0.030
0.001 (−0.002–0.003)
0.502
NS
Inflammatory markers
CRP
—
—
—
—
0.414
0.406 (0.334–0.479)
9.1 × 10−26
2.9 × 10−24
SAA
0.414
0.423 (0.347–0.498)
9.1 × 10−26
2.9 × 10−24
—
—
—
—
Fibrinogen
0.308
0.002 (0.002–0.003)
1.4 × 10−14
4.5 × 10−13
0.178
0.001 (0.001–0.002)
1.4 × 10−5
4.5 × 10−4
sE-selectin
0.272
0.681 (0.486–0.877)
1.8 × 10−11
5.8 × 10−10
0.101
0.251 (0.051–0.451)
0.014
0.448
sP-selectin
0.044
0.071 (−0.059–0.200)
0.287
NS
−0.004
−0.007 (−0.136–0.122)
0.916
NS
sVCAM1
0.032
0.154 (−0.235–0.544)
0.436
NS
0.028
0.131 (−0.252–0.515)
0.502
NS
sICAM1
0.126
0.331 (0.120–0.541)
0.002
0.064
0.019
0.049 (−0.160–0.258)
0.645
NS
sTNFRII
0.180
0.753 (0.421–1.084)
1.0 × 10−5
3.2 × 10−4
0.073
0.299 (−0.034–0.631)
0.078
NS
IL6
0.316
0.468 (0.372–0.564)
9.5 × 10−15
3.1 × 10−14
0.165
0.197 (0.102–0.291)
4.9 × 10−5
0.002
MCP1
0.031
0.05 (−0.080–0.180)
0.452
NS
0.012
0.019 (−0.112–0.150)
0.772
NS
MMP1
0.045
0.045 (−0.036–0.126)
0.275
NS
−0.002
−0.002 (−0.082–0.078)
0.959
NS
MMP2
−0.119
−0.469 (−0.784 to −0.154)
0.004
0.128
−0.043
−0.235 (−0.548–0.078)
0.297
NS
MMP9
0.077
0.146 (−0.007–0.299)
0.062
NS
0.076
0.145 (−0.008–0.297)
0.064
NS
Adipokines
Leptin
0.225
0.442 (0.325–0.559)
2.8 × 10−8
9.0 × 10−7
0.131
0.289 (0.169–0.409)
0.001
0.032
Resistin
0.082
0.150 (0.000–0.301)
0.050
NS
−0.019
−0.034 (−0.183–0.116)
0.659
NS
Lipocalin-2
0.136
0.310 (0.124–0.495)
0.001
0.032
0.085
0.190 (0.005–0.376)
0.044
NS
Adiponectin
−0.251
−0.447 (−0.586 to −0.308)
5.3 × 10−10
1.7 × 10−8
−0.007
−0.013 (−0.155–0.129)
0.862
NS
value was adjusted for age and sex. Adjust values were computed by Bonferroni method, NS (not significant) if adjusted value above 1.0. Abbreviations are as in Table 1; BP levels, lipid variables, and uric acid levels were analyzed with the exclusion of subjects using antihypertensive drugs, lipid-lowering agents, and uric acid lowering agents, respectively. Fasting plasma glucose and insulin, QUICKI, and HOMA-IR index were analyzed with the exclusion of antidiabetic medications. Albumin-to-creatinine ratio (ACR) (mg/g) was analyzed with the exclusion of subjects with macroalbuminuria.
