Research Article
CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects
Table 4
Associations of the CRP and SAA haplotypes with respective circulation levels in subjects from health examination.
| | Haplotypes | Frequency | CRP levels | SAA levels | | Gene | Coefficient | value (adjusted ) | Coefficient | value (adjusted ) | Coefficient | value (adjusted ) | Coefficient | value (adjusted ) |
| | CRP | | | | | | | | | | | ACGCA | 51.8% | −0.1601 | 2.66 × 10−3 | NA | NA | 0.0054 | 0.9230 | 0.0710 | 0.1684 | | GCGCG | 18.3% | −0.0089 | 0.8973 | NA | NA | 0.0073 | 0.9184 | 0.0179 | 0.7855 | | AAGCG | 16.0% | 0.3120 | 1.447 × 10−5 (8.68 × 10−5) | NA | NA | −0.0535 | 0.4804 | −0.1884 | 0.0077 (0.046) | | ACCCA | 7.0% | −0.2349 | 0.0268 | NA | NA | −0.0252 | 0.8201 | 0.0692 | 0.4987 | | ATGTG | 3.3% | 0.2551 | 0.0809 | NA | NA | 0.0121 | 0.9371 | −0.1074 | 0.4482 | | ACGCG | 2.0% | 0.2759 | 0.1290 | NA | NA | 0.1746 | 0.3547 | 0.0649 | 0.7090 | | SAA | | | | | | | | | | | GATT | 36.8% | −0.130 | 0.0189 | 0.1321 | 0.0213 | −0.6147 | 6.92 × 10−29 (4.15 × 10−28) | NA | NA | | AAAC | 29.6% | 0.0537 | 0.3601 | −0.2507 | 3.18 × 10−5 (1.91 × 10−4) | 0.6451 | 2.10 × 10−28 (1.20 × 10−27) | NA | NA | | AGTC | 24.5% | 0.1145 | 0.0725 | 0.1208 | 0.0404 | −0.0024 | 0.9712 | NA | NA | | GAAC | 5.4% | 0.0643 | 0.5872 | −0.0020 | 0.9848 | 0.1499 | 0.2240 | NA | NA | | AGTT | 1.9% | 0.0830 | 0.6654 | 0.0247 | 0.8913 | 0.1920 | 0.3464 | NA | NA |
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to values: definitions as in Table 3.
For the adjusted value, only significant values were demonstrated, NA: not available.
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