CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects
Table 5
Mediation test of CRP and SAA levels in the association of CRP and SAA1 genotypes/haplotypes with SAA and CRP levels.
SAA variants for CRP level
CRP haplotype for SAA level
rs4638289#
rs7131332#
rs11024591#
AAAC
AAGCG
Criterion 1
Regression coefficient
−0.040
−0.044
−0.047
0.645
0.312
Standard error
0.004
0.005
0.005
0.055
0.071
value
3.87 × 10−26
1.79 × 10−19
7.37 × 10−20
2.10 × 10−28
1.45 × 10−5
Criterion 2
Regression coefficient
0.460
0.420
0.424
0.460
0.429
Standard error
0.041
0.040
0.040
0.041
0.040
value
7.43 × 10−27
1.23 × 10−23
5.24 × 10−24
2.28 × 10−26
2.73 × 10−24
Regression coefficient
0.017
0.012
0.014
−0.251
−0.188
Standard error
0.004
0.005
0.005
0.060
0.070
value
1.24 × 10−5
0.014
0.007
3.18 × 10−5
0.008
Criterion 3
Regression coefficient
−0.002
−0.006
−0.006
0.054
−0.054
Standard error
0.004
0.005
0.005
0.059
0.076
value
0.555
0.187
0.220
0.360
0.480
Criterion 4
Regression coefficient
−0.018
−0.018
−0.020
0.297
0.134
Standard error
0.002
0.003
0.003
0.037
0.033
value (Sobel test)
<10−8
<10−8
<10−8
<10−8
4.78 × 10−5
Represent SAA genotypes were analyzed in additive models. : unstandardized coefficient for the association between SAA1 variants and log adiponectin levels or between CRP variants and log CRP levels. : unstandardized coefficient for the association between SAA and CRP levels. Direct effect = . Total effect = . Mediation (indirect) effect = αβ.
