Interaction between TLR-mediated activation and endocannabinoid system. PAMPs and DAMPs provide dangers signals that activate innate immune cells via TLRs. Activated cells increase endocannabinoid levels that may suppress the inflammatory response. Cell activation may increase or decrease cannabinoid receptor expression. Increased receptor expression in the presence of endocannabinoids promotes immune suppression. Decreased receptor expression may render cells resistant to cannabinoid-mediated immune suppression, and the inflammatory response continues. PAMPs: pathogen-associated molecular patterns; DAMPs: damage-associated molecular patterns; TLR: Toll-like receptors; CB: cannabinoid.