Review Article
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Table 2
Cannabinoid effects on in vivo TLR responses.
| Animal model | Cell or tissue | Effect | Reference |
| LPS | Blood & brain | ↓ inflammatory cytokines | Roche et al. [112] | CB1R & CB2R-mediated | | Cardiovascular system | ↓ hypotensive response | Gallily et al. [115] | Blood | ↓ tumor necrosis factor-α | | ↑ survival | |
| LPS-induced pulmonary inflammation | Bronchoalveolar fluid | ↓ tumor necrosis factor-α | Berdyshev et al. [113] | Lungs | ↓ neutrophil infiltration | | CB2R-mediated | |
| C. parvum/LPS | Blood | ↓ inflammatory cytokines | Smith et al. [114] | ↑ survival | | CB1R-mediated | |
| D-Galactosamine/LPS | Liver | ↓ inflammatory cytokine | Tomar et al. [116] | ↑ interleukin-10 | | ↓ acute liver failure | | ↓ cell infiltration | | CB2R-mediated | | ↑ survival | Gallily et al. [115] |
| Sepsis in CB2R−/− mice | Blood | ↑ interleukin-6 | Tschöp et al. [118] | Lungs | ↑ tissue damage | | ↓ survival | |
| CB2R−/− mice | | ↑ incidence & severity of induced inflammatory various diseases | Reviewed in Buckley [15] & Malfitano et al. [117] |
| CB1R/CB2R−/− mice | | ↑ contact dermatitis | Karsak et al. [119] | | ↑ delayed-type hypersensitivity | | | ↑ Influenza-induced inflammation | Buchweitz et al. [120] | Alveolar macrophages | More mature phenotype | Karmaus et al. [121] | Dendritic cells | More mature phenotype | |
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