Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

Table 2

Cannabinoid effects on in vivo TLR responses.

Animal model	Cell or tissue	Effect	Reference
LPS	Blood & brain	↓ inflammatory cytokines	Roche et al. [112]
		CB1R & CB2R-mediated
	Cardiovascular system	↓ hypotensive response	Gallily et al. [115]
	Blood	↓ tumor necrosis factor-α
		↑ survival
LPS-induced pulmonary inflammation	Bronchoalveolar fluid	↓ tumor necrosis factor-α	Berdyshev et al. [113]
	Lungs	↓ neutrophil infiltration
		CB2R-mediated
C. parvum/LPS	Blood	↓ inflammatory cytokines	Smith et al. [114]
		↑ survival
		CB1R-mediated
D-Galactosamine/LPS	Liver	↓ inflammatory cytokine	Tomar et al. [116]
		↑ interleukin-10
		↓ acute liver failure
		↓ cell infiltration
		CB2R-mediated
		↑ survival	Gallily et al. [115]
Sepsis in CB2R^−/− mice	Blood	↑ interleukin-6	Tschöp et al. [118]
	Lungs	↑ tissue damage
		↓ survival
CB2R^−/− mice		↑ incidence & severity of induced inflammatory various diseases	Reviewed in Buckley [15] & Malfitano et al. [117]
CB1R/CB2R^−/− mice		↑ contact dermatitis	Karsak et al. [119]
		↑ delayed-type hypersensitivity
		↑ Influenza-induced inflammation	Buchweitz et al. [120]
	Alveolar macrophages	More mature phenotype	Karmaus et al. [121]
	Dendritic cells	More mature phenotype