Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016 (2016), Article ID 5953498, 6 pages
http://dx.doi.org/10.1155/2016/5953498
Research Article

Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer

1Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
2Department of Obstetrics & Gynecology, Nanshan Hospital, Shenzhen, Guangdong 518052, China
3Department of Obstetrics & Gynecology, Xinxiang Central Hospital, Xinxiang, Henan 453600, China
4Department of Obstetrics & Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
5Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China

Received 21 March 2016; Accepted 12 June 2016

Academic Editor: Shintaro Iwata

Copyright © 2016 Zhaoxia Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. C. Wang, X. N. Huang, J. R. Zhang et al., “The expression of VEGF and Dll4/Notch pathway molecules in ovarian cancer,” Clinica Chimica Acta, vol. 436, pp. 243–248, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Stewart and C. P. Wild, World Cancer Report 2014, World, 2015.
  3. J.-H. Choi, J. T. Park, B. Davidson, P. J. Morin, I.-M. Shih, and T.-L. Wang, “Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion,” Cancer Research, vol. 68, no. 14, pp. 5716–5723, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. L. C. Cantley, “The phosphoinositide 3-kinase pathway,” Science, vol. 296, no. 5573, pp. 1655–1657, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. C. K. M. Ip, A. N. Y. Cheung, H. Y. S. Ngan, and A. S. T. Wong, “p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells,” Oncogene, vol. 30, no. 21, pp. 2420–2432, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. S. T. Wong, C. D. Roskelley, S. Pelech, D. Miller, P. C. K. Leung, and N. Auersperg, “Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation,” Experimental Cell Research, vol. 299, no. 1, pp. 248–256, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Y. Zhou and A. S. T. Wong, “Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells,” Endocrinology, vol. 147, no. 5, pp. 2557–2566, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake, “Notch signaling: cell fate control and signal integration in development,” Science, vol. 284, no. 5415, pp. 770–776, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Hay and N. Sonenberg, “Upstream and downstream of mTOR,” Genes and Development, vol. 18, no. 16, pp. 1926–1945, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Hopfer, D. Zwahlen, M. F. Fey, and S. Aebi, “The Notch pathway in ovarian carcinomas and adenomas,” British Journal of Cancer, vol. 93, no. 6, pp. 709–718, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Mirone, S. Perna, A. Shukla, and G. Marfe, “Involvement of notch-1 in resistance to regorafenib in colon cancer cells,” Journal of Cellular Physiology, vol. 231, no. 5, pp. 1097–1105, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. Y.-Z. Ye, Z.-H. Zhang, X.-Y. Fan et al., “Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer,” Medical Oncology, vol. 30, no. 2, article 595, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Yuan, H. Wu, H. X. Xu et al., “Notch signaling: an emerging therapeutic target for cancer treatment,” Cancer Letters, vol. 369, no. 1, pp. 20–27, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Yuan, H. Wu, N. Han et al., “Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application,” Journal of Hematology and Oncology, vol. 7, article 87, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Hu, T. Liu, C. Ivan et al., “Notch3 pathway alterations in ovarian cancer,” Cancer Research, vol. 74, no. 12, pp. 3282–3293, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. J.-G. Jung, A. Stoeck, B. Guan et al., “Notch3 interactome analysis identified WWP2 as a negative regulator of notch3 signaling in ovarian cancer,” PLoS Genetics, vol. 10, no. 10, Article ID e1004751, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. A. M. Egloff and J. R. Grandis, “Molecular pathways: context-dependent approaches to notch targeting as cancer therapy,” Clinical Cancer Research, vol. 18, no. 19, pp. 5188–5195, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. L. Pon, H. Y. Zhou, A. N. Y. Cheung, H. Y. S. Ngan, and A. S. T. Wong, “p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells,” Cancer Research, vol. 68, no. 16, pp. 6524–6532, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. W. Groeneweg, R. Foster, W. B. Growdon, R. H. Verheijen, and B. R. Rueda, “Notch signaling in serous ovarian cancer,” Journal of Ovarian Research, vol. 7, article 95, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. M.-A. Bjornsti and P. J. Houghton, “The TOR pathway: a target for cancer therapy,” Nature Reviews Cancer, vol. 4, no. 5, pp. 335–348, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Palomero, M. L. Sulis, M. Cortina et al., “Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia,” Nature Medicine, vol. 13, no. 10, pp. 1203–1210, 2007. View at Publisher · View at Google Scholar · View at Scopus