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Mediators of Inflammation
Volume 2016, Article ID 5962946, 8 pages
Research Article

Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis

1Department of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland
2Department of Esthetic Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland
3Department of Hematological Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland
4Department of Surgery, Public Health Hospital, 19-100 Monki, Poland

Received 12 April 2016; Accepted 12 June 2016

Academic Editor: Czar L. Gaston

Copyright © 2016 Monika Zajkowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Breast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation. We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women). Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA. VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC. VEGF was also the only parameter which has statistically significant AUC in all stages of cancer. M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC. These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC. Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases.