Chemokine receptor Chemokine(s) Roles Reference(s) CXCR5 CXCL13 Targets : B cells, B1 cells, Role : promote both systemic response and local renal inflammation[24 , 26 , 30 –32 , 34 ] CXCR4 CXCL12 Targets : B cells, CD4+ Foxp3+ T cells, CD4+ Foxp3− T cells, plasma cells, neutrophils, monocytes, PECRole : promote both systemic response and local renal inflammation[39 –42 , 44 ] CXCR3 CXCL9 Targets : CD4+ T cells, CD8+ T cells, B220+ cells, plasma cells, macrophagesRole : promote local renal inflammation in MRL/lpr mice[23 , 48 , 49 ] CCR1 CCL3, 5 Targets : T cells, monocytes/macrophagesRole : promote local renal inflammation[26 , 50 , 51 ] CCR5 CCL3, 5 Targets : T cells, Foxp3+ Treg cells, macrophagesRole : negatively regulate systemic response and local renal inflammation[51 –53 ] CCR2 CCL2 Target : macrophagesRole : promote both systemic response and local renal inflammation[52 , 54 –59 ] CX3CR1 CX3CL1 Target : CD16+ cellsRole : promote local renal inflammation[60 , 61 ]