Association of Serum Adropin Concentrations with Diabetic Nephropathy

Table 1

Clinical characteristics of T2DM patients and controls.

	Control	T2DM patients
		Normoalbuminuria	Microalbuminuria	Macroalbuminuria
	81	110	95	40
Age (years)	58.35 ± 7.80	57.52 ± 11.33	58.45 ± 13.16	59.92 ± 10.78	0.701
Gender (M/F)	46/35	58/521	49/46	21/19	0.911
BMI (Kg/m^2)	25.73 ± 2.84	26.06 ± 3.99	26.50 ± 3.52	26.33 ± 3.07	0.512
SBP (mmHg)	122.52 ± 11.28	135.50 ± 22.26	147.63 ± 29.95	156.65 ± 23.26	<0.001
DBP (mmHg)	79.10 ± 7.45	80.45 ± 14.26	88.00 ± 19.60	86.08 ± 12.74	0.001
HbA1c (%)	4.76 ± 0.32	7.85 ± 1.43	8.06 ± 1.23	7.96 ± 1.67	<0.001
TG (mmol/L)	2.08 ± 1.58	1.89 ± 1.10	2.16 ± 1.92	2.05 ± 1.11	0.626
TC (mmol/L)	5.23 ± 0.90	5.09 ± 1.07	5.45 ± 1.26	5.32 ± 1.02	0.115
HDL-C (mmol/L)	1.49 ± 0.25	1.12 ± 0.24	1.13 ± 0.21	1.17 ± 0.33	<0.001
LDL-C (mmol/L)	3.25 ± 0.54	3.39 ± 0.89	3.69 ± 1.03	3.52 ± 0.80	0.006
BUN (nmol/L)	5.37 ± 1.18	5.33 ± 1.58	5.91 ± 1.98	8.63 ± 3.94	<0.001
Cr (μmol/L)	66.46 ± 10.37	65.27 ± 18.16	66.33 ± 21.27	115.47 ± 70.72	<0.001
ACR (mg/g)	—	15.94 ± 4.45	93.51 ± 80.98	>300	<0.001
GFR (mL/min/1.73 m^2)	101.77 ± 11.85	109.90 ± 38.96	109.13 ± 33.39	70.50 ± 35.65	<0.001
Adropin (ng/mL)	3.71 (2.82–4.56)	3.17 (2.63–3.68)	2.85 (2.32–3.27)	2.56 (2.07–2.85)	<0.001
MetS (%)	4 (4.94%)	73 (66.36%)	68 (71.56%)	33 (82.5%)	<0.001

Significant versus control subjects.
Significant versus T2DM patients with normoalbuminuria.
Significant versus T2DM patients with microalbuminuria.
T2DM, type 2 diabetes mellitus; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BUN, blood urea nitrogen; Cr, creatinine; ACR, urine albumin to creatinine ratio; GFR, glomerular filtration rate; MetS, metabolic syndrome.