C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function

Figure 8

Cleavage sites in the AAT reactive center loop (RCL). Shown are the known cleavage sites in the RCL (italic) of AAT with respective enzymes gathered from the MEROPS database [29]. Human proteases are displayed in black and proteases of other species in grey. Also for every cleavage site the respective molecular weight of the C-terminal peptide is indicated. Cleavage between Phe³⁵² and Leu³⁵³ leads to the generation of CAAP48 (red frame). However in the presence of SNP rs1303 cleavage at this site leads to the generation of CAAP47, a peptide with an substitution at the position indicated in blue.