C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function

Table 1

Patient characteristics.

	Sepsis	SIRS; cardiac surgery	SIRS; traumatic injury	HIV
	19	19	17	23
Age (years, mean ± SD)	63.05 ± 15.29	68.89 ± 7.43	39.29 ± 14	39 ± 14.97
Gender (m/f)	11/8	11/8	12/5	17/6
SOFA (mean ± SD)	11.42 ± 3.55	10.21 ± 3.97	10.76 ± 2.44	—
Procalcitonin ([ng/mL], median (range))	5.34 (163.9)	7.28 (159.24)	0.49 (20.2)	0.07  (0.24)
Mechanical ventilation (%)	84.2	68.4	94.1	—
MDI/CDI	13/6	0/0	0/0	23/0
Pathogen (gram^+/gram^−/fungal/mixed infection/viral)	4/7/1/1/0	0/0/0/0/0	0/0/0/0/0	0/0/0/0/23
HIV titer (<100/100–10000/>10000)	—	—	—	9/6/8
Staphylococcus aureus	2	—	—	—
Escherichia coli	4	—	—	—
Enterobacter	1	—	—	—
Klebsiella	2	—	—	—
Candida (other than albicans)	1	—	—	—
Enterococcus	3	—	—	—

SOFA score: Sequential Organ Failure Assessment Score. Subscores on SOFA range from 0 to 4 for each of six organ systems, with an aggregate score of 0 to 24 and with higher scores indicating more severe organ dysfunction.
Procalcitonin values were determined in 18 out of 23 HIV patients, MDI: microbiologically documented infection, CDI: clinically suspected infection.