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Mediators of Inflammation
Volume 2016, Article ID 6235614, 14 pages
http://dx.doi.org/10.1155/2016/6235614
Research Article

Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses

Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China

Received 7 December 2015; Revised 13 February 2016; Accepted 15 February 2016

Academic Editor: Vera L. Petricevich

Copyright © 2016 Wujing Dai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Th17 response was enhanced by blocking the Wnt/β-catenin pathway. Expression of IL-21 (A) and RORγt (B) in lung were assayed by realtime RT-PCR using the −ΔΔCt method. Values are shown as mean ± SEM (n=4-5). (*, as compared with saline group at the same time point, p<0.05; #, as compared with silica group and silica+NC shRNA group at the same time point, p<0.05).

  1. Supplementary Figure