The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE^−/− Mice

Figure 3

Dapagliflozin attenuated the formation of atherosclerotic lesion in ApoE^−/− mice. (a) Oil red O staining of thoracic aorta and abdominal aorta. Numbers 1–5 indicated diabetic treatment group, diabetic control group, nondiabetic treatment group, nondiabetic control group, and C57BL/6J control group, respectively; (b) oil red O staining of aortic roots (100x); (c) HE staining of aortic roots (100x), the small black arrow showed lesions and the big black arrow showed the necrotic lipid core of lesions; (d) percentage of arterial lesions in aorta; (e) percentage of lesions at aortic root in lumen cross-sectional area; ; .

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