The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE^−/− Mice

Figure 4

Influence of dapagliflozin on cellular formation (macrophage infiltration and smooth muscle cells) in atherosclerotic lesion in the aorta. Numbers 1–5 indicated diabetic treatment group, diabetic control group, nondiabetic treatment group, nondiabetic control group, and C57BL/6J control group, respectively. (a) Macrophage infiltration in atherosclerotic lesions (red: macrophages; blue: nuclei); (b) smooth muscle cell infiltration in atherosclerotic lesions (red: α-SMA antibody labeled smooth muscle cells; blue: DAPI-labeled nuclei); (c) immunofluorescence optimal density of MOMA2 antibody; (d) immunofluorescence optimal density of α-SMA antibody. ; .

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