The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE^−/− Mice

Figure 5

Dapagliflozin attenuated the formation of ROS and NLRP3 inflammasome in DM ApoE^−/− mice. Decreased ROS formation in aortic tissues of diabetic ApoE^−/− mice was attenuated by dapagliflozin treatment (a). The expression of NLRP3 inflammasome, IL-1β, and IL-18 in aortic tissues of mice from each group (b). Western blot analysis was used to detect the protein expression levels with the antibodies against NLRP3, ASC, caspase-1, IL-1β, and IL-18. GAPDH was used as loading control (c). ; .

(a)

(b)

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