Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters
Table 1
Comparison of general clinical and laboratory parameters in the four subgroups.
Group
NGT-NW
NGT-OB
T2DM-NW
T2DM-OB
Sex (M/F)
38 (20/18)
40 (19/21)
37 (19/18)
46 (17/29)
Age
59.24 ± 8.42
58.55 ± 8.03
58.62 ± 7.92
61.13 ± 6.33
SBP (mmHg)
114.84 ± 8.10
117.95 ± 14.34
115.38 ± 8.21
114.17 ± 6.76
DBP (mmHg)
71.92 ± 6.53
70.80 ± 8.86
72.16 ± 8.10
76.48 ± 8.19
Weight (kg)
52.40 ± 6.67
67.01 ± 7.40
53.28 ± 7.55
67.20 ± 8.16
WC (cm)
74.68 ± 6.03
87.58 ± 6.54
77.70 ± 7.74
90.53 ± 7.18
HC (cm)
89.19 ± 4.53
98.47 ± 5.13
90.21 ± 4.87
99.49 ± 6.15
WHR
0.84 ± 0.05
0.89 ± 0.05
0.86 ± 0.06
0.91 ± 0.06
BMI
21.54 ± 2.11
26.83 ± 1.56
21.86 ± 1.90
27.44 ± 2.29
FPG (mmol/L)
5.44 ± 0.38
5.37 ± 0.40
6.62 ± 1.26
6.95 ± 0.97
2 h PG (mmol/L)
6.29 ± 1.24
6.48 ± 1.46
12.50 ± 2.03
12.26 ± 1.76
HbA1c (%)
5.79 ± 0.29
5.85 ± 0.29
6.19 ± 0.60
6.73 ± 0.96
FINS (mU/L)
4.57 ± 1.23
7.18 ± 3.29
7.03 ± 4.31
9.66 ± 3.82
HOMA-IR
1.11 ± 0.31
1.73 ± 0.81
2.13 ± 1.49
3.00 ± 1.33
HDL-C (mmol/L)
1.53 ± 0.42
1.28 ± 0.28
1.31 ± 0.45
1.13 ± 0.32
LDL-C (mmol/L)
2.24 ± 0.71
2.48 ± 0.89
2.58 ± 0.64
2.77 ± 0.68
TC (mmol/L)
4.25 ± 1.00
4.34 ± 1.22
4.54 ± 0.86
4.91 ± 0.96
TG (mmol/L)
1.07 ± 0.46
1.60 ± 0.83
1.42 ± 0.63
1.77 ± 0.61
TNF-α (pg/mL)
6.42 ± 3.59
8.89 ± 3.05
8.01 ± 3.48
9.70 ± 3.53
IL-6 (pg/mL)
68.08 ± 21.61
90.53 ± 31.36
111.09 ± 43.23
115.54 ± 34.13
Data are presented as the means ± SD. Differences between multiple groups were tested by ANOVA for continuous variables. NGT, normal glucose tolerance; T2DM, type 2 diabetes mellitus; NW, normal weight; OB, obesity; SBP, systolic blood pressure; DBP, diastolic blood pressure; WC, waist circumference; HC, hip circumference; WHR, waist-hip ratio; BMI, body mass index; FPG, fasting plasma glucose; 2 h PG, 2 h postchallenge plasma glucose; HbA1c, glycated hemoglobin; FINS, fasting serum insulin; HOMA-IR, homeostasis model assessment for insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride; TNF-α, tumor necrosis factor α; IL-6, interleukin-6. compared with NGT-NW and compared with NGT-NW; compared with NGT-OB and compared with NGT-OB; compared with T2DM-NW and compared with T2DM-NW.
