Research Article
Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment
Figure 6
Disturbed expression of EphB4, but not ephrinB2, significantly retarded bone regeneration in an inflammatory microenvironment created in mice. (a–i) At 7 days (a–c), 14 days (d–f), and 21 days (g–i) after surgery, new bone tissue could be observed in the pLenti6.3-ctrl group (a, d, g), the pLenti6.3-efnb2siRNA group (b, e, h), and the pLenti6.3-ephb4siRNA group (c, f, i). (j) Statistical analysis of the newly formed bone area among the three groups; nb, new bone; scale bars, 50 μm; versus pLenti6.3-ctrl group.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |
(h) |
(i) |
(j) |