Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis

Figure 2

Expression of CAT in the iris and ciliary bodies detected by immune-fluorescence staining. Vel-L = low-dose bortezomib; Vel-H = high-dose bortezomib; CAT-1 and CAT-2 were immunostained as red. In the “Merge” column (b, d, f, h, j and l, n, p, r, t), all of the slices were counterstained with DAPI (4′,6-diamidino-2-phenylindole) that stains blue for better iris-ciliary body tissue visualization. CAT-1 was extensively expressed in the ICBs of all the treatment groups (c, e, g, and i), whereas CAT-2 was expressed only in the LPS- (o) and low-dose bortezomib-treated groups (q). High-dose bortezomib (s) treatment reduced the CAT-2 expression in the ICBs of EIU rats. Scale bar = 50 μm.