Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

Table 1

HMTs and DNMT involved in macrophage polarisation.

Name	Family	Function	References
HMTs	—	IL-6, IL-12, TNF-α, NO secretion induction, and IL-1β secretion inhibition	[30]
SETDB1	KMT1	TNF repression	[31]
EHMT2	KMT1	Ifnβ and ISG suppression	[32]
EHMT1, EHMT2	KMT1	M2-IL-4 activation status	[33]
MLL	KMT2	CXCL10 induction	[34]
MLL4	KMT2	CD14 membrane anchoring	[35]
Ash1	KMT2	A20 production and IL-6 suppression	[36]
SETD1A, ASH1, MLL3, and MLL4	KMT2	M2-IL-4 activation status	[33]
SMYD2	KMT3	Tnf, Il6, MHC-II, and CD40/80 suppression	[37]
SMYD3	KMT3	Alox15 induction	[34]
SMYD5	KMT3	Il1α, Il1β, Ccl4, Tnf, and Cxcl10 repression	[38]
SUV420H2 and SETD8	KMT5	M2-IL-4 activation status	[33]
EZH1	KMT6	M2-IL-4 activation status	[33]
DNMT	—	Cfb, Serping, Tnfsf15 induction; Arg1, Nrp1, Cxcr4, Plxnd1, Cdk18, and Fes repression	[39]
DNMT1	—	Socs1 silencing	[40]
DNMT1 and DNMT3b	—	Cystathionine--lyase suppression	[41]
DNMT3B	—	PPAR- silencing and polarisation to M1 phenotype	[42]
DNMT3A and DNMT3L	—	M2-IL-4 activation status	[33]