Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

Table 2

DMTs involved in macrophage polarisation.

Name	Family	Function	References
AOF1	KDM1	Mdc, Il12b, and Ip10 induction	[43]
KDM2A	KDM2	M2-IL-4 activation status	[33]
JMJD2D	KDM4	Il12b and Mdc induction	[44]
JMJD3/UTX	KDM6	TNF-α secretion	[45]
JMJD3	KDM6	NF-kB, CD40, and IFN signalling	[46]
JMJD3	KDM6	IL-12/IL-10 increase	[47]
JMJD3	KDM6	Il12b, Il23a, G-CSF, and Trem1 induction	[48]
JMJD3	KDM6	Arginase-1, CD206 induction, TNF-α, and IL-6 repression	[49]
JMJD3	KDM6	Arg1, Retnla, and Chi3l3 induction	[50]
JMJD3	KDM6	Arg1, Fizz1, Ym1, Mrc1, and Il13 induction	[51]
JMJD3	KDM6	Irf4 induction	[49, 51]
PHF2	KDM7	Tnf, Ccl4, Cxcl10, Il1a, Il1b, Il6, Ccl5, Irf1, Mx1, and Oas3 induction	[38]
TET2	TET	Il6 repression	[52]