Thyroid Hormones, Oxidative Stress, and Inflammation

Figure 2

Both hyperthyroidism and hypothyroidism can cause oxidative stress but with different mechanisms. We speculate that nonthyroidal illness syndrome (NTIS) may represent a tissue hypothyroidism condition linked to intracellular and systemic oxidative stress. MDA: malondialdehyde; NO: nitric oxide; PON-1: paraoxonase-1; RNS: reactive nitrogen species; ROS: reactive oxygen species; TAC: total antioxidant capacity.