Recent Advances in Antiviral Therapy for Chronic Hepatitis C

Table 2

Profile of NS5A inhibitors.

Generation			Active against HCV genotype	Genetic barriers	Resistant association variants
1st	BMS-790052	Daclatasvir	1b > 2a > 1a	Moderate			L31F/M/V	Y93C/H/N
1st	GS-5885	Ledipasvir	1a, 1b	Moderate			L31F/M/V	Y93C/H/N
1st	ABT-267	Ombitasvir	1 > 2–6	Moderate	M28T	Q30E/R		Y93C/H/N
Broad activity	MK-8742	Elbasvir	1–4	Unavailable	M28T	Q30L/R	L31<	Y93H/N
2nd	GS-5816	Velpatasvir	1–6	Unavailable
2nd	ACH-3102		1–5	High				Y93H

Reference [23] Kohler et al. 2014.