Recent Advances in Antiviral Therapy for Chronic Hepatitis C

Table 3

Profile of NS5B inhibitors.

		Binding site	Active against HCV genotype	Genetic barriers	Resistant association variants
Nucleotide
GS-7977	Sofosbuvir		1a, 1b, and 2–6	High	S282T
Nonnucleoside
BMS-791325	Beclabuvir	Site I		Moderate	A421V	P495S/Q/L/A/T
ABT-333	Dasabuvir	Site III		Moderate	C316Y/N	S368T	M414T/I/V/L	Y448C/H	G554D/S	S556G	D559G
GS9669		Site II		Moderate	L419S	R422K	M423T/I/V/T	I482L/V/T	A486/V/I/T/M	V494A
MK-3682				Moderate

Reference [16] Vermehren and Sarrazin 2012.