Cytokines and Effector/Regulatory Cells Characterization in the Physiopathology of Cutaneous Lupus Erythematous: A Cross-Sectional Study

Figure 2

Tissue architecture, cytokines, CD4 effector T cells, and regulatory cells in cutaneous lupus erythematosus. (a) Representative photomicrograph from a HD (healthy donor), HSc (hypertrophic scar), DLE (discoid lupus erythematosus), and SCLE (subacute cutaneous lupus erythematosus) tissues stained by H&E technique. Original magnification was ×160. Immunohistochemistry for (b) IL-22, (c) CD4/IL-17A, (d) CD4/IL-4, (e) CD4/IFN-γ, (f) CD25/Foxp3, (g) CD20/IL-10, and (h) CD123/IDO cells. Arrows depict immunoreactive cells. Original magnification was ×320.

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