Cytokines and Effector/Regulatory Cells Characterization in the Physiopathology of Cutaneous Lupus Erythematous: A Cross-Sectional Study
Table 2
Cytokine expression and regulatory cells in tissue from patients with cutaneous lupus erythematosus.
Epidermis
Dermis
HD ()
HSc ()
DLE ()
SCLE ()
HD ()
HSc ()
DLE ()
SCLE ()
IL-22-expressing cells (%)
Mean ± SEM
5.7 ± 0.7
15.6 ± 0.5
23.4 ± 2.1
16.1 ± 1.8
4.7 ± 1.0
17.3 ± 0.8
28.9 ± 2.5
17.0 ± 1.9
Median
5.0
16.0
21.0
16.0
3.0
17.5
28.0
19.0
Range
2.0–10.5
14.0–18.0
7.0–49.0
2.0–5.5
1.0–14.0
15.0–22.0
8.0–55.0
7.0–31.0
IL-17A-expressing CD4+ cells (%)
Mean ± SEM
2.8 ± 0.5
5.0 ± 0.7
27.1 ± 1.8
11.9 ± 1.5
2.1 ± 0.5
4.1 ± 0.5
29.5 ± 1.8
12.4 ± 1.1
Median
2.0
5.0
24.0
13.0
2.0
4.5
28.5
13.5
Range
1.0–8.0
2.0–8.0
19.0–44.0
3.0–21.0
0.0–7.0
1.0–6.0
20.0–50.0
4.0–18.0
IL-4-expressing CD4+ cells (%)
Mean ± SEM
3.0 ± 0.9
8.5 ± 0.9
12.6 ± 1.4
11.0 ± 1.1
3.2 ± 0.9
13.8 ± 0.5
12.3 ± 1.3
11.8 ± 1.5
Median
2.0
9.0
12.0
10.5
2.5
14.0
13.0
11.0
Range
0.5–15.0
3.0–14.0
4.0–25.0
5.5–18.0
0.0–13.0
12.0–17.0
1.5–21.0
4.0–22.0
IFN-γ-expressing CD4+ cells (%)
Mean ± SEM
2.2 ± 0.5
7.5 ± 0.8
11.0 ± 0.8
8.0 ± 1.4
2.5 ± 0.7
9.0 ± 0.5
11.3 ± 0.7
7.7 ± 1.1
Median
2.0
8.0
10.0
6.0
2.0
9.0
11.0
6.0
Range
0.0–6.0
2.0–11.0
4.5–18.0
2.5–22.0
0.0–9.0
7.0–12.0
0.5–18.0
3.5–16.0
Foxp3-expressing CD25+ cells (%)
Mean ± SEM
5.4 ± 1.0
45.9 ± 1.1
14.8 ± 1.1
12.5 ± 1.2
5.4 ± 1.2
55.1 ± 0.8
17.8 ± 1.1
15.0 ± 1.1
Median
5.0
45.5
16.0
12.0
3.0
56.0
17.5
15.0
Range
1.0–14.0
40.0–52.0
3.5–23.0
7.0–24.0
0.5–15.0
50.0–58.0
11.0–27.0
9.0–22.0
IL-10-expressing CD20+ cells (%)
Mean ± SEM
7.3 ± 1.2
11.4 ± 0.6
10.9 ± 0.8
8.9 ± 1.4
8.8 ± 1.5
16.7 ± 0.8
12.9 ± 1.2
12.3 ± 1.3
Median
5.5
10.5
10.5
8.0
6.5
16.0
13.0
11.3
Range
2.0–15.0
9.0–14.0
3.0–18.0
1.0–15.5
2.0–20.0
13.0–22.0
1.5–23.0
6.0–24.0
IDO-expressing CD123+ cells (%)
Mean ± SEM
4.0 ± 0.7
17.1 ± 1.6
9.9 ± 0.9
5.0 ± 1.0
4.0± 0.5
20.7 ± 1.2
12.7 ± 1.2
8.2 ± 0.9
Median
4.0
16.0
8.5
4.0
4.0
20.0
11.0
8.0
Range
1.0–11.0
12.0–26.0
4.0–18.0
1.0–12.0
1.0–8.0
16.0–26.0
4.5–29.0
4.0–16.0
HD: healthy donors; HSc: hypertrophic scar; DLE: discoid lupus erythematosus; SCLE: subacute cutaneous lupus erythematosus. HD versus HSc: ; HD versus DLE: ; HD versus SCLE: ; HSc versus DLE: ; HSc versus SCLE: ; DLE versus SCLE: .
